Molgramostim is a recombinant human granulocyte macrophage colony stimulating factor (rHuGM-CSF), produced by recombinant DNA technology using E.coli. It is a 127 amino acid protein, non-glycosylated, and has a molecular weight of approximately 14.5kD.
1.In patients receiving myelosuppressive therapy cancer chemotherapy to reduce the severity of neutropenia, thereby reducing the risk of infection and allowing better adherence to the chemotherapeutic regimen;
2.In patients undergoing autologous or syngeneic bone marrow transplantation to accelerate myeloidrecovery (Molgramostim does not improve overall survivalor increase time to relapse);
Sterile and white lyophilized powder to be reconstituted with a diluent (Sterile Water for Injection)forinjection, presented in vials.
Dosage: 50μg,75μg,100μg,150μg, 300μg and 400μg
Reference: Current EP/CP/Internal
Specific activity: ≥1.0×107IU/mg
Purity (HPLC, SDS-PAGE): ≥98%
Active ingredients: Molgramostim (rHuGM-CSF)
In active ingredients: Mannitol, Macrogol 4000, Human Albumin, Dibasic Sodium Phosphateand Monobasic Potassium Phosphate.
lShelf life and storage conditions
Storage at 2
Drug Substance (Concentrated solution)
Storage at -70