Filgrastim is a recombinant human granulocyte colonystimulating factor (rHuG-CSF), produced by recombinant DNA technology using E.coli. It is a 175 amino acid protein, non-glycosylated, and has a molecular weight of approximately 18.8kD. The protein has an amino acid sequence that is identical to the natural sequence predicted from human DNA sequence analysis, except for the addition of an N-terminal methionine necessary for expression in E. coli.
1.Neutropenia resulting from cancer chemotherapy.
2.Neutrophil decrease after bone marrow transplantation.
3.Neutropenia caused by Myelodysplastic syndrome, neutropenia caused by aplastic anemia; congenital neutropenia, idiopathic neutropenia, Myelodysplastic syndrome with neutropenia and Periodic neutropenia.
4.Patients undergoing peripheral blood progenitor cell collection and therapy.
Sterile, clear and colorless liquid for injection in vial
Dosage: 75μg,100μg,150μg, 200μg,300μg and 480μg
Reference: Current CP/Internal
Specific activity: ≥0.8×108IU/mg
Purity (HPLC, SDS-PAGE): ≥98%
Active ingredients: Filgrastim (rHuG-CSF).
Inactive ingredients: Glacial Acetic Acid, Mannitol, Polysorbate 80 and Sodium Acetate.
lShelf life and storage conditions
Storage at 2
Drug Subastance (Concentrated solution)
Storage at 2-8